Developed skills and lines of research

Andrea Armirotti received his MS degree in Chemistry in 2002 and Ph.D. in Biochemistry in 2006 from the University of Genoa. He is currently a research technologist at the Istituto Italiano di Tecnologia in Genoa, where he directs the new Analytical Chemistry facility.

His research activity focuses mainly on proteomics and metabolomics, characterizing the changes that occur in biological systems as a result of various stimuli, from drugs to gene silencing. He is also involved in new research in the field of biomarkers. For cystic fibrosis, he is working on novel molecular targets to improve recovery of CFTR-F508del from that achieved by early corrector drugs. He is co-author of more than 100 international publications and co-inventor of two patents.

Projects funded by FFC Ricerca as Principal Investigator or as Research Manager

FFC#1/2023
Investigation of Kaftrio secondary effects on sphingolipid synthesis

FFC#1/2021
Multiomics exploration of the CF primary bronchial epithelium lipidome and its role on CFTR rescue

FFC#1/2019
Proteomic profiling of F508del-CFTR cells to identify new pharmacological targets for CF

FFC#1/2018
Proteomic profiling of F508del-CFTR cells to identify new pharmacological targets for CF

Publications from FFC Research projects

Braccia C, Tomati V, Caci E, et al., SWATH label-free proteomics for cystic fibrosis research. J Cyst Fibros. 2018 Oct 19. pii: S1569-1993(18)30855-5. doi: 10.1016/j.jcf.2018.10.004. [Epub ahead of print]

Andrea Armirotti, Valeria Tomati, Elizabeth Matthes, et al. Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. Sci Rep, 9 (1), 10310 2019 Jul 16