Developed skills and lines of research
Fabio Bertozzi graduated in Chemistry and Pharmaceutical Technology (CTF) from the University of Pisa in 1998. In 2002, he received his PhD in Organic Chemistry from the Department of Bioorganic Chemistry, University of Pisa. During this period, he spent eight months as an undergraduate student at the University of Groningen (NL) in the group of Prof. B. L. Feringa (2016 Nobel Prize in Chemistry). In March 2002, he moved to the biotechnology company ACADIA Pharmaceuticals (Copenhagen – DK) for a one-year postdoctoral fellowship. Since January 2013, Dr. Bertozzi has been a research technologist at the Italian Institute of Technology (IIT). This role became permanent in November 2017. Since 2015, Dr. Bertozzi has contributed to the development of FFC Ricerca’s strategic project geared toward identifying new compounds for the treatment of cystic fibrosis (Task Force for Cystic Fibrosis). Through his work, he helped identify the novel CFTR corrector (ARN23765), which was selected as a preclinical development candidate for the treatment of CF. He is now working to characterize the mechanism of action of CFTR modulators through a photo-activation-induced tagging technique.
Patents with FFC Ricerca
1.Heterocyclic derivatives for the treatment of cystic fibrosis
a. Inventori: Bandiera Tiziano; Bertozzi Fabio; Di Fruscia Paolo; Sorana Federico; Berti
Francesco; Rodriguez Gimeno Alejandra; Caci Emanuela; Ferrera Loretta; Pedemonte
Nicoletta; Galietta Luis Juan Vicente.
b. Titolari: Fondazione Istituto Italiano Tecnologia (IIT), Istituto Giannina Gaslini, FFC Ricerca.
2.Compounds and compositions for the treatment of cystic fibrosis
a. Inventori: Bandiera Tiziano; Bertozzi Fabio; Di Fruscia Paolo; Sorana Federico; Berti
Francesco; Rodriguez Gimeno Alejandra; Caci Emanuela; Ferrera Loretta; Pedemonte
Nicoletta; Galietta Luis Juan Vicente.
b. Titolari: Fondazione Istituto Italiano Tecnologia (IIT), Istituto Giannina Gaslini, FFC Ricerca.
3.Pyrazole derivatives for the treatment of cystic fibrosis
a. Inventori: Bandiera Tiziano; Bertozzi Fabio; Di Fruscia Paolo; Sorana Federico; Caci Emanuela; Ferrera
Loretta; Pedemonte Nicoletta; Galietta Luis Juan Vicente.
b. Titolari: Fondazione Istituto Italiano Tecnologia (IIT), Istituto Giannina Gaslini, FFC Ricerca.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#2/2022
Characterization of CFTR modulators mechanism of action via Photo-Affinity Labeling (PAL) approach
FFC#4/2020
Characterization of CFTR modulators mechanism of action via Photo-Affinity Labeling (PAL) approach