Developed skills and lines of research

Marco Colombatti received his medical degree in 1978 from the University of Padua. Since 1998 he has been an associate professor at the Section of Immunology, Department of Pathology, University of Verona. Since 1985 he has carried out research at the Institute of Immunology and Infectious Diseases of the University of Verona (now Section of Immunology, Department of Pathology) regarding the mechanisms of action of antibody/ligand-toxin conjugates with particular attention to possible applications in the immunotherapy of brain tumors. He has also been interested in biological and functional aspects concerning brain tumor-derived cells. More recently, his research activity has turned to the study of prostate cancer immunotoxins as well as experimental aspects concerning mechanisms of T-lymphocyte response and functional interactions between MBP-specific T-lymphocytes and human astrocytes. For cystic fibrosis, he has been involved in developing a method to have potential correctors released within diseased cells by binding the drug to a transporter protein (human albumin).

Projects funded by FFC Ricerca as Principal Investigator or as Research Manager

FFC#1/2006
Novel methods of intracellular delivery of ΔF508-CFTR correctors

FFC#1/2004
Dissection of folding/defolding processes in CFTR and ∆F508 – CFTR cells. Use of disarmed toxins to target chaperones and assist refolding and expression of AF508 – CFTR.

Publications from FFC Research projects

C Norez, M Pasetto, MC Dechecchi et al. Chemical conjugation of ΔF508-CFTR corrector deoxyspergualin to transporter human serum albumin enhances its ability to rescue Cl− channel functions. American Journal of Physiology, 2008, Volume 295;2:336-347 https://doi.org/10.1152/ajplung.00059.2008