Developed skills and lines of research
Since 2005, Cecilia Garlanda has been director at Humanitas Research Hospital, in Milan, where she leads the Experimental Immunopathology Lab, as well as associate professor at Humanitas University. Previously, she served as Research Unit Director (Experimental Immunopathology) in the Immunology Laboratory of the Mario Negri Institute in Milan, where she worked as a researcher from 1991.
Her research in the field of CF aims to identify new strategies to combat Pseudomonas aeruginosa-induced infection and inflammation.
Her scientific contributions include numerous invited talks at conferences and courses, over 300 international publications, many chapters in scientific books, and multiple abstracts presented at conferences.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#15/2014
Infections in cystic fibrosis patients: effect of PTX3 genetic variants on endogenous PTX3 production and function
FFC#18/2010
Infections in cystic fibrosis: role of the long pentraxin PTX3 in host resistance and as therapeutic agent
FFC#14/2008
Infections in cystic fibrosis: role of the long pentraxin PTX3 in host resistance and as therapeutic agent
Projects financed by FFC Ricerca as a partner
FFC#18/2011
Inflammasome activation and IL-1β mediated inflammation triggered by Pseudomonas aeruginosa: a rationale for novel therapeutic approaches in cystic fibrosis patients
Publications from FFC Research projects
Bottazzi B, Garlanda C, Cotena A et al. The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity. Immunol Rev. 2009 Jan;227(1):9-18. doi: 10.1111/j.1600-065X.2008.00719.x.
Moalli F, Doni A, Deban L et al. Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood, 2010 Dec 9;116(24):5170-80. doi: 10.1182/blood-2009-12-258376. Epub 2010 Sep 9.
Bottazzi B, Doni A, Garlanda C, Mantovani A. An integrated view of humoral innate immunity: pentraxins as a paradigm. Annu Rev Immunol. 2010;28:157-83. doi: 10.1146/annurev-immunol-030409-101305.
Moalli F, Paroni M, Véliz Rodriguez T et al. The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa. J Immunol. 2011 May 1;186(9):5425-34. doi: 10.4049/jimmunol.1002035. Epub 2011 Mar 25.
Riva F, Bonavita E, Barbati E et al. TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity. Front Immunol, 2012 Oct 29;3:322. doi: 10.3389/fimmu.2012.00322. eCollection 2012.
Garlanda C, Riva F, Bonavita E et al. Decoys and Regulatory “Receptors” of the IL-1/Toll-LikeReceptor Superfamily. Front Immunol, 2013 Jul 9;4:180. doi: 10.3389/fimmu.2013.00180. eCollection 2013.
Chiarini M, Sabelli C, Melotti P et al. PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients. Genes Immun. 2010 Dec; 11(8): 665–670. doi: 10.1038/gene.2010.41
Inforzato A, Jaillon S, Moalli F, et al. The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling. Tissue Antigens. 2011 Apr;77(4):271-82. doi: 10.1111/j.1399-0039.2011.01645.x.
Inforzato A, Bottazzi B, Garlanda C, et al. Pentraxins in humoral innate immunity. Adv Exp Med Biol. 2012;946:1-20. doi: 10.1007/978-1-4614-0106-3_1.
Doni A, Garlanda C, Bottazzi B, et al. Interactions of the humoral pattern recognition molecule PTX3 with the complement system. Immunobiology. 2012 Nov;217(11):1122-8. doi: 10.1016/j.imbio.2012.07.004.
Véliz Rodriguez T, Moalli F, Polentarutti N, et al. Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection. Infect Immun. 2012 Jan;80(1):100-9. doi: 10.1128/IAI.05695-11. Epub 2011 Oct 24.
Paroni M, Moalli F, Nebuloni M, t al. Response of CFTR-deficient mice to long-term chronic Pseudomonas aeruginosa infection and PTX3 therapy. J Infect Dis. 2013 Jul;208(1):130-8. doi: 10.1093/infdis/jis636. Epub 2012 Oct 18.
Garlanda C, Riva F, Bonavita E, Mantovani A. Negative regulatory receptors of the IL-1 family. Semin Immunol. 2013 Dec 15;25(6):408-15. doi: 10.1016/j.smim.2013.10.019. Epub 2013 Nov 14.