Developed skills and lines of research

Annalisa Guaragna is an Associate Professor at the Department of Chemical Sciences, University of Naples “Federico II.”

She graduated in Biological Sciences and earned her PhD in Chemical Sciences from the same university. She leads a Medicinal Chemistry laboratory dedicated to the synthesis and study of new molecular systems with pharmacological potential in various therapeutic areas. In recent years, her research has focused on developing small molecules for therapeutic approaches to rare diseases, particularly those caused by protein misfolding defects.

For FFC Ricerca, Annalisa Guaragna investigates new antimicrobial/anti-inflammatory agents for treating lung infections in people with cystic fibrosis. Her recent studies, largely funded by FFC Ricerca, explore iminosugar-based glycomimetics as potential alternatives to conventional antibiotics, often associated with resistance issues.

She has authored approximately 80 articles in peer-reviewed international journals, four invited book chapters, and numerous oral and poster presentations at national and international conferences. She also holds a patent related to the pharmacological activity of new iminosugars.

Projects funded by FFC Ricerca as Principal Investigator or as Research Manager

FFC#8/2024
A combined therapy against Pseudomonas aeruginosa-Staphylococcus aureus co-infections in cystic fibrosis

FFC#13/2020
Can old and new sweet glycomimetics act as antibacterial and antibiofilm agents in the treatment of CF lung disease infections?

Projects financed by FFC Ricerca as a partner

FFC#20/2019
Evaluation of anti-inflammatory treatments for CF lung disease in murine models of lung infection in vivo: insights on the anti-inflammatory effect of β-sitosterol and anti-inflammatory/anti-infective activity of L-miglustat

FFC#23/2018
Evaluation of anti-inflammatory treatments for CF lung disease in murine models of lung infection in vivo