Developed skills and lines of research

Paolo Landini graduated in Biological Sciences from the University of Pavia in 1986. In 1989, he specialized in Microbiology at the University of Pavia and earned a PhD in Biochemistry from the University of Birmingham in 2000. Since 2007, he has been a Full Professor at the Department of Biosciences of the University of Milan.

The main research lines developed in his laboratory include studying the expression of adhesion and biofilm formation genes in Gram-negative bacteria, investigating inhibitors of biofilm formation, and exploring specific promoter recognition by RNA polymerase associated with different sigma factors.

Projects funded by FFC Ricerca as Principal Investigator or as Research Manager

FFC#18/2015
Antimetabolite drugs as inhibitors of Pseudomonas aeruginosa biofilm growth and virulence: potential chemotherapics and tools in target identification for new antimicrobials

FFC#13/2009
Prevention of Pseudomonas aeruginosa biofilm formation by inhibition of cyclic-di-GMP (c-di-GMP) metabolism

FFC#9/2006
Counteracting Pseudomonas aeruginosa biofilm formation by inhibition of novel targets: regulation of the levels of the di-cyclic-GMP signal molecule

Publications from FFC Research projects

Antoniani D., Bocci P., Maciag A. et al., Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors. Applied Microbiology and Biotechnology, 2009, 85(4):1095-104

Antoniani D., Rossi E., Rinaldo S. et al., The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability. Applied Microbiology and Biotechnology, 2013, 97(16):7325-36

Giardina G., Paiardini A., Fernicola S. et al., Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain. PLoS One, 2013, 8(11):e81324