Developed skills and lines of research
Paolo Pinton has been a Full Professor of General Pathology at the University of Ferrara since 2015, within the Department of Morphology, Surgery, and Experimental Medicine. Prof. Pinton has extensive research experience in signal transduction in living cells and the applications of advanced imaging with luminescent and fluorescent probes. He is one of the world’s leading experts on calcium homeostasis and the role of mitochondria in physiological and pathological contexts. He leads a 400-square-meter laboratory with a team of over 30 researchers. As of 2023, he had authored more than 300 publications listed in Medline, with a total Impact Factor of 2,000. In cystic fibrosis, his work has addressed pulmonary inflammation caused by P. aeruginosa and its potential therapeutic targets.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#19/2014
Mitochondrial Ca2+-dependent inflammasome activation exacerbates the P. aeruginosa-driven inflammatory response
FFC#12/2010
Calcium signal and PKC as targets of Pseudomonas aeruginosa infection
Projects financed by FFC Ricerca as a partner
FFC#19/2011
Phospholipase C beta (PLCB) as candidate therapeutic target in CF lung proinflammatory signaling
Publications from FFC Research projects
Bononi A, Agnoletto C, De Marchi E et al. Protein kinases and phosphatases in the control of cell fate. Enzyme Res. 2011;2011:329098. doi: 10.4061/2011/329098. Epub 2011 Sep 4
Giorgi C, Agnoletto C, Bononi A et al. Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion. 2012 Jan;12(1):77-85. doi: 10.1016/j.mito.2011.07.004. Epub 2011 Jul 21.
Patergnani S, Suski JM, Agnoletto C et al. Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal. 2011 Sep 22;9:19. doi: 10.1186/1478-811X-9-19.
Pinton P, Giorgi C, Pandolfi PP. The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites. Cell Death Differ. 2011 Sep;18(9):1450-6. doi: 10.1038/cdd.2011.31. Epub 2011 Apr 8.
Bonora M, Patergnani S, Rimessi A, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57. doi: 10.1007/s11302-012-9305-8. Epub 2012 Apr 12.
Giorgi C, Baldassari F, Bononi A, et al. Mitochondrial Ca(2+) and apoptosis. Cell Calcium. 2012 Jul;52(1):36-43. doi: 10.1016/j.ceca.2012.02.008. Epub 2012 Apr 3.
Marchi S, Marinello M, Bononi A et al. Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis. Cell Death Dis. 2012 May 3;3:e304. doi: 10.1038/cddis.2012.45.
Patergnani S, Marchi S, Rimessi A et al. PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy. Autophagy. 2013 Sep;9(9):1367-85. doi: 10.4161/auto.25239. Epub 2013 Jun 11.
Rimessi A, Bezzerri V, Patergnani S et al. Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis. Nat Commun. 2015 Feb 4;6:6201. doi: 10.1038/ncomms7201.