Developed skills and lines of research
Since 1998, Claudio Sorio has been an Associate Professor of General Pathology at the University of Verona. He graduated in Medicine from the University of Verona and the University of Padua in 1988. He subsequently obtained a PhD in Pathology and, in 1998, a specialization in Surgical Pathology. Since 2012, he has also been the head of the C.F.T.R. (Cystic Fibrosis Translational Research) laboratory at the Department of Pathology and Diagnostics. His research in the CF field is mainly focused on the evaluation of CFTR activity on monocytes, with the development of a new test aimed at measuring the effect of new drugs on blood monocytes of subjects with CF having stop or gating mutations.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#13/2018
Testing intestinal organoids for the prediction of response to CFTR potentiators and correctors used in clinic
FFC#29/2015
Testing CFTR repair in cystic fibrosis patients carrying nonsense and channel gating mutations
FFC#6/2013
Establishment of a semi-automated evaluation of CFTR function in blood cells for clinical applications
FFC#26/2011
Testing human monocytes as a new tool for clinical and preclinical research in CF
FFC#5/2009
Functional evaluation of CFTR in blood leukocytes in human subjects as a new tool for diagnostic and clinical research applications
Projects financed by FFC Ricerca as a partner
FFC#6/2010
Novel biomarkers for evaluation of efficacy of new therapies in cystic fibrosis
FFC#15/2008
Effects of azithromycin (AZM) on Pseudomonas aeruginosa-induced chronic lung inflammation in cystic fibrosis
FFC#17/2006
Roles of azithromycin other than bactericidal: relevance for therapy of cystic fibrosis
FFC #10/2005
Roles of azithromycin other than bactericidal: relevance for therapy of cystic fibrosis
Publications from FFC Research projects
Sorio C, Melotti P. Editorial: The role of macrophages and their scavenger receptors in cystic fibrosis. J Leukoc Biol. 2009 Sep;86(3):465-8. doi: 10.1189/jlb.0309120.
Sorio C, Buffelli M, Angiari C, et al. Defective CFTR Expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis. PLoS One, 2011;6(7):e22212. doi: 10.1371/journal.pone.0022212. Epub 2011 Jul 21.
Ettorre M, Verzè G, Caldrer S, et al. Electrophysiological evaluation of Cystic Fibrosis Conductance Transmembrane Regulator (CFTR) expression in human monocytes. Biochim Biophys Acta, 2014 Oct;1840(10):3088-95. doi: 10.1016/j.bbagen.2014.07.010. Epub 2014 Jul 18.
Johansson J, Vezzalini M, Verzè G, et al. Detection of CFTR protein in human Leukocytes by Flow Cytometry. Cytometry A, 2014 Jul;85(7):611-20. doi: 10.1002/cyto.a.22456. Epub 2014 Mar 12.
Bellisola G, Caldrer S, Cinque G et al. The identification of cystic fibrosis (CF) cells and their pharmacological correction by mid-infrared microspectroscopy and unsupervised data analysis methods. Science Letters Journal, 2014, 3:51
Caldrer S, Verzè G, Johansson J et al. Challenging the diagnosis of cystic fibrosis in a patient carrying the 186-8T/C allelic variant in the CF transmembrane conductance regulator gene. BMC Pulm Med. 2014 Mar 13;14:44. doi: 10.1186/1471-2466-14-44.
Averna M, Bavestrello M, Cresta F et al. Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients. Arch Biochem Biophys. 2016 Aug 15;604:103-12. doi: 10.1016/j.abb.2016.06.015. Epub 2016 Jun 25.
Sorio C, Montresor A, Bolomini-Vittori M, et al. Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency. Am J Respir Crit Care Med, 2016 May 15;193(10):1123-33. doi: 10.1164/rccm.201510-1922OC.
Bergamini G, Stellari F, Sandri A. An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses. J Vis Exp. 2017 Jul 7;(125). doi: 10.3791/55499.
Sara Caldrer, Gabriella Bergamini, Angela Sandri, et al. Cystic Fibrosis Transmembrane Conductance Regulator Functional Evaluations in a G542X+/- IVS8Tn:T7/9 Patient With Acute Recurrent Pancreatitis. World J Clin Cases, 7 (22), 3757-3764 2019 Nov 26.