Developed skills and lines of research
Mario Strazzabosco graduated in Medicine and Surgery in 1982 from the University of Padua and specialized in Internal Medicine. Today he is a Professor of Gastroenterology at the University of Milan Bicocca and Director of the Master’s programs in Transplant Medicine. Prof. Strazzabosco’s scientific activity is documented by over 200 publications in leading international journals. His main research interests concern the pathophysiology of biliary tract diseases, the biology of hepatic stem cells, liver transplantation, and hepatocellular carcinoma. He is the director of a research group that deals with the cellular and molecular biology of the liver. In the field of liver pathology, he has produced research concerning cystic fibrosis.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#24/2015
CFTR-defective biliary cells from human induced pluripotent-stem cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver disease
FFC#18/2012
Cystic Fibrosis liver disease: the role of CFTR as regulator of epithelial innate immunity
FFC#11/2003
Pathogenesis and treatment of cystic fibrosis-related liver disease
Publications from FFC Research projects
Strazzabosco M, Fabris L, Spirli C. Pathophysiology of cholangiopathies. J Clin Gastroenterol. 2005 Apr;39(4 Suppl 2):S90-S102.
Spirlì C, Fiorotto R, Song L et al. Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism. Gastroenterology. 2005 Jul;129(1):220-33.
Strazzabosco M, Fiorotto R, Melero S, et al. Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology, 2009 Jul;50(1):244-52. doi: 10.1002/hep.22926.
Scirpo R, Fiorotto R, Villani A, et al. Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium. Hepatology 2015 Nov;62(5):1551-62. doi: 10.1002/hep.28000. Epub 2015 Aug 28.
Fouassier L, Fiorotto R. Ezrin finds its groove in cholangiocytes. Hepatology. 2015 May;61(5):1467-70. doi: 10.1002/hep.27675. Epub 2015 Mar 19.
Fiorotto R, Villani A, Kourtidis A, et al. CFTR controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology, 2016 Dec;64(6):2118-2134. doi: 10.1002/hep.28817. Epub 2016 Oct 27.
Fiorotto R, Amenduni M, Mariotti V et al. Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy. Hepatology. 2017 Jul 24. doi: 10.1002/hep.29400. [Epub ahead of print]
Strazzabosco M, Fiorotto R, Cadamuro M, et al. Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1374-1379. doi: 10.1016/j.bbadis.2017.07.023. Epub 2017 Jul 25.