Developed skills and lines of research
Anna Tamanini has a degree in Biological Sciences and was a Biologist Manager at the Clinical Chemical and Hematological Analysis Laboratory of the hospital of Verona. Her experience in the field of cystic fibrosis spans over a decade. In her research activity, she has studied the role of particular proteins in the interaction with the CFTR protein and Pseudomonas aeruginosa infection. She is currently involved in studies aimed at improving the efficacy of modulators of the mutated CFTR-F508del protein, acting on the sphingolipids of the cell membrane, the site of CFTR action.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#9/2015
Identification of molecular targets to reduce the side effect of gating potentiators on the F508del-CFTR plasma membrane stability
FFC#8/2010
Decreased apical expression of CFTR by Pseudomonas aeruginosa infection: role of NHERF1 phosphorylation
FFC#4/2004
Role of Adenovirus Receptors in the activation of Mitogen-Activated Protein Kinase pathways and Nuclear Factor – kB in human airways epithelial cells
Projects financed by FFC Ricerca as a partner
FFC#1/2022
A lipid-based therapeutic approach to rescue CFTR with orphan mutations and implications in bacterial infections in cystic fibrosis
FFC#2/2020
Lipid-based therapeutic strategies to optimize the effectiveness of innovative drugs to rescue F508del-CFTR
FFC#7/2019
Targeting the signalling network controlling proteostasis and inflammation to rescue F508del-CFTR
FFC#2/2018
Development of ganglioside GM1-based therapy to improve F508delCFTR rescue approaches
Publications from FFC Research projects
Tamanini A, Nicolis E, Bonizzato A, et al. Interaction of Adenovirus type 5 fiber with the Coxsackie Adenovirus receptor activates inflammatory response in human respiratory cells. J Virol, 2006 Nov;80(22):11241-54. Epub 2006 Sep 6.
Rubino R, Bezzerri V, Favia M et al. Pseudomonas aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1. Pflugers Arch. 2014 Dec;466(12):2269-78. doi: 10.1007/s00424-014-1474-6. Epub 2014 Mar 5.
Schiumarini D, Loberto N, Mancini G et al. Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells. Mediators Inflamm. 2017;2017:1730245. doi: 10.1155/2017/1730245. Epub 2017 Dec 3.